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According to the UK product information, the most frequently reported adverse effects include: Nausea and diarrhoea very common (affecting at least 10% of patients) Vomiting, constipation and abdominal pain common (affecting between 1% and 10% of patients) Dyspepsia (indigestion) common (affecting between 1% and 10% of patients) Flatulence and bloating commonly reported but less frequently documented in trials These gastrointestinal effects are dose-dependent, meaning they tend to be more pronounced at higher doses (0.5-2mg)

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This was the first time that COFs was reported for the photodynamic therapy of tumors

[5] For patients using semaglutide for weight management, inconsistent dosing may affect appetite suppression patterns and potentially compromise weight loss results